Immunomodulatory effects of medicinal plants used for vitiligo in traditional Persian medicine

Vitiligo is a hypopigmentation disorder that affects 1% of the world’s population. Vitiligo causes white spots on the skin, mucous membranes, or white hair by destroying skin melanocytes. The pathogenesis of vitiligo is unknown, but autoimmune, autocytotoxic, and neural mechanisms are suggested.

According to the autoimmune theory, in people with vitiligo, immune cells invade and damage melanocytes. T cells are more commonly present in vitiligo patients’ skin and remain in the lesion site, which is composed of CD8 and CD4 T cells. Many studies have been conducted on the presence and role of cytokines such as interleukins and interferon gamma (IFN-γ) in the vitiligo process.

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